文摘
摘要目的:来描述的,相关的风险因素,和严重的神经系统表现的结果(脑病、中风、癫痫和meningo-encephalitis)患者冠状病毒疾病住院2019 (COVID-19)。
背景:虽然案例系列比比皆是,存在有限的前瞻性多中心数据描述神经COVID-19的表现
设计/方法:前瞻性观察研究的住院成人与实验室确认的SARS-CoV-2感染在24个国家的179家医院中SCCM发现病毒感染和呼吸道疾病大学的研究(病毒)COVID-19注册表
结果:在注册表中登记的16225名患者与放电状态,2092年(12.9%)于1656年严重的神经系统症状包括与脑病(10.2%)承认,331年(2.0%)和中风,243与癫痫发作(1.5%)和73(0.5%)与脑膜炎或脑炎在住院或住院治疗。严重的神经系统症状患者年龄与中值(差)72岁(61.0 - -81.0)和61年(48.0 - -72.0)和慢性病患病率较高,包括血管危险因素。系统性病毒症状(发热、呼吸困难和咳嗽)患者一般不报道严重神经系统表现为温和的神经症状包括嗅觉缺失症,味觉障碍,头痛。调整性和次大流行爆发以来,相关的严重的神经系统症状更严重的疾病(或1.82,p < 0.001),定义的顺序疾病严重程度的规模。患者神经系统症状更容易被承认ICU(或1.45,p < 0.001)和ICU干预(ECMO:或1.78,p = 0.009和RRT:或1.99,p < 0.001)。医院和28天神经症状患者的死亡率高(或1.51和1.58,p < 0.001),患者少ICU-free hospital-free, ventilator-free天(或−0.84−1.34,−0.84,p < 0.001)。
结论:脑病在COVID-19入学是常见的感染和与较差的预后相关。而严重的神经系统症状包括中风、癫痫、脑炎和脑膜炎/不太常见,都与ICU支持利用率,增加更严重的疾病,甚至更糟。
披露:Cervantes-Arslanian博士没有披露。Venkata博士没有披露。Anand博士没有披露。伯恩斯博士已经收到个人补偿的范围为0 - 499美元作为一个编辑,副主编,或为爱思唯尔编辑顾问委员会成员。王博士没有披露。LeMahieu女士没有披露。舒尔特教授已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会OxThera。Rabinstein博士已经收到个人薪酬在5000 - 9999美元的范围为在科学咨询服务或数据安全监测委员会波士顿科学。Rabinstein博士已经收到个人薪酬在5000 - 9999美元的范围为在科学咨询服务或数据安全监测委员会Boerhinger-Ingelheim。Rabinstein博士已经收到个人补偿的范围0 - 499美元为科学顾问或服务数据安全监测委员会Minnetronix。 Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Astra Zeneca. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurocritical care/NCS-Springer. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wolters/UptoDate. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for EBSCO/DynaMed. The institution of Dr. Rabinstein has received research support from EyeBox. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Kumar has nothing to disclose. Dr. Walkey has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Thoracic Society. The institution of Dr. Walkey has received research support from NIH. Dr. Walkey has received publishing royalties from a publication relating to health care.
