胃肠道症状的作用,降钙素相关基因肽Migraine-Clinical考虑

CGRP Activity in the GI Tract and Downstream Effects (A) Autonomic innervation of the gastrointestinal tract (Adapted from Snell. Clinical Neuroanatomy, 7th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2010,^e15 and adapted and reprinted by permission from Springer Nature: Capsaicin Receptor as Target of Calcitonin Gene-Related Peptide in the Gut by Evangelista¹¹ S, 2014). (B) TRPV1 activation and CGRP response (Reproduced from Assas et al. Calcitonin gene-related peptide is a key neurotransmitter in the neuroimmune axis. Front Neurosci 2014; 8[23]: 469–497).^e23 (C) CGRP binding dependent on CGRP receptor subunit composition. The bar charts indicate relative ligand activity when binding human receptors. (Adapted and reprinted by permission from Springer Nature: Neurology and Therapy “Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor,” Blumenfeld et al., 2021)^e24 Abbreviations: AMY1 = amylin receptor 1; CGRP = calcitonin gene-related peptide; CLR = calcitonin-like receptor; CSM = circular smooth muscle; CTR = calcitonin receptor; DRG = dorsal root ganglion; LSM = longitudinal smooth muscle; MP = myenteric plexus; NG = nodose ganglion; PIP2 = phosphatidylinositol 4,5-bisphosphate; SMP = submucosal plexus; RAMP = receptor activity modifying protein; RAMP1 = RAMP type 1; TRPV1 = transient receptor potential vanilloid 1.