文摘
客观的识别自我抑郁和焦虑症状的患病率在缓解患者自身免疫性脑炎(AE)。
背景尽管之前的研究已经发现了一种盛行的残余认知障碍患者在缓解AE,有一个缺乏这类患者长期精神结果数据。在正常人群,中位数病人健康Questionaire-9 (PHQ9)和一般焦虑Disorder-7 (GAD7)分数据报道,分别为3和2左右,与抑郁和焦虑症状的患病率在这些问卷调查报告为24%和23%左右。
设计/方法回顾横断面队列研究在三级中心AE诊所在2012-01-01和2012-01-01之间。患者通过电话联系或定期随访和PHQ9和GAD7完成。
结果41例患者联系;29(71%)和包括回应。17(59%)是女性。平均年龄为32.5岁(范围5 - 77)。n -甲基- d受体自身抗体结果(n = 14人,48%)、负(n = 7, 24%),富亮氨酸glioma-inactivated 1 (n = 6 21%),和contactin-associated蛋白质像2 (n = 1, 3%)。从发病到问卷收集的平均时间为6.3年(范围1.5 - -23.0)。10例(37%)出现抑郁的症状以PHQ9, 6(60%)报告严重的症状。PHQ9得分中位数为3(范围0-18)。6个病人(22%)GAD7出现焦虑的症状,用一个(17%)报告严重的症状。GAD7得分中位数为2(范围清廉)。 Eight patients (28%) reported a psychiatric history prior to the onset of AE, which was associated with increased PHQ9 scores (p = 0.04, Wilcoxon rank sum test).
结论自我抑郁和焦虑症状的患病率在这个组在缓解AE是类似于一般人群。之前有精神病史患者发病的AE PHQ9较高分数。这些结果可能会影响到审查的偏见和低敏感性的自我报告的诊断工具。
脚注
披露:Gabarin先生没有披露。赫伯特博士没有披露。Climans博士没有披露。Muccilli博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会生原体。Muccilli博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会诺华。Muccilli博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会EMD Serono。李医生没有披露。天已收到博士个人薪酬在5000 - 9999美元的范围为Parabon Nanolabs担任顾问。天已收到博士个人薪酬制度在5000 - 9999美元的范围为礼来公司担任顾问。天已收到博士个人薪酬在500 - 4999美元的范围作为一个编辑,副主编,或编辑顾问委员会成员力学(EBSCO健康)。 Dr. Day has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Barrow Law. Dr. Day has stock in ANI Pharmaceuticals. The institution of Dr. Day has received research support from National Institutes of Health / NIA. The institution of Dr. Day has received research support from Chan Zuckerberg Initiative. The institution of Dr. Day has received research support from Alzheimer's Association. The institution of Dr. Day has received research support from National Institutes of Health / NINDS. The institution of Dr. Day has received research support from Horizon Therapeutics. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Presenter at Annual Meeting (CME) with American Academy of Neurology. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Content Development (CME) with PeerView, Inc. Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Content Development (CME) with Continuing Education, Inc. Dr. Day has a non-compensated relationship as a Clinical Director with AntiNMDA Receptor Encephalitis Foundation that is relevant to AAN interests or activities. Dr. Wennberg has nothing to disclose. Dr. Tang-Wai has nothing to disclose.
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