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Hypersexual behavior has been reported after brain injury and may be manifested by an increased libido, a change in sexual orientation, or a change in sexual disinhibition. Hypersexuality has no proven treatment,1 although reports have described reductions in hypersexual behavior using antiandrogen treatment.2,3 Cimetidine, a histamine H2-receptor antagonist, has been shown to be a nonhormonal antiandrogen in rats.4 A systematic study of the treatment of hypersexual behavior in patients with dementia has not been reported. The purpose of this study is to retrospectively evaluate the impact of cimetidine, a nonhormonal antiandrogen, on patients with dementia who exhibit organic hypersexual behavior.
The study protocol was approved by The Ohio State University Human Subjects Review Committee. The sample population consisted of 20 patients …
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