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March 27, 2001; 56 (6) Brief Communications

Preliminary evidence of widespread morphological variations of the brain in dyslexia

W. E. Brown, S. Eliez, V. Menon, J. M. Rumsey, C. D. White, A. L. Reiss
First published March 27, 2001, DOI: https://doi.org/10.1212/WNL.56.6.781
W. E. Brown
BA
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S. Eliez
MD
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V. Menon
PhD
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J. M. Rumsey
PhD
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C. D. White
BA
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A. L. Reiss
MD
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Citation
Preliminary evidence of widespread morphological variations of the brain in dyslexia
W. E. Brown, S. Eliez, V. Menon, J. M. Rumsey, C. D. White, A. L. Reiss
Neurology Mar 2001, 56 (6) 781-783; DOI: 10.1212/WNL.56.6.781

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Abstract

The MR images of 16 men with dyslexia and 14 control subjects were compared using a voxel-based analysis. Evidence of decreases in gray matter in dyslexic subjects, most notably in the left temporal lobe and bilaterally in the temporoparietooccipital juncture, but also in the frontal lobe, caudate, thalamus, and cerebellum, was found. Widely distributed morphologic differences affecting several brain regions may contribute to the deficits associated with dyslexia.

  • Received July 3, 2000.
  • Accepted December 5, 2000.
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