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To the Editor:
Xu et al. report that they failed to prove the hypothesis that MRI-derived measures of the entorhinal cortex (EC) are superior to hippocampal measures in the early diagnosis of AD.1 They compared their published MRI hippocampal volume method against their adaptation of two published anatomically validated MRI methods to evaluate the EC. The first EC method, developed by Insausti, was a volume determination.2-4⇓⇓ The second method, developed at New York University, measured the surface area of the EC. Xu et al. concluded that little difference was observed between the measurements, and that after considering the anatomic ambiguities and artifacts associated with EC measurement, overall, the hippocampal measure was preferred.
As the authors of the two prior MRI-EC publications, we are writing to express our concern that Xu et al. did not correctly employ our methods and, therefore, that their conclusion is premature.
By taking the rostral limit of the hippocampus as the anterior boundary of the EC, one neglects a considerable anterior portion …
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