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Fronto-Subcortical Circuits in Psychiatric and Neurologic Disorders
edited by David G. Lichter and Jeffrey L. Cummings,
ill., New York, The Guilford Press, 2001
The concept that corticobasal ganglia circuitry is organized in parallel loop systems was advanced by Alexander et al. in 1986 and has been a widely influential model in understanding neuropsychiatric disease. Dr. Jeffrey Cummings, a co-editor of this volume, was one of the early pioneers in considering the anatomic bases of complex behavioral syndromes using this model. Since then, both basic and clinical scientists have used this concept of corticobasal ganglia circuits to interpret clinical, imaging, and pathologic findings in neuropsychiatric diseases. The chapters in this book are written by leading neuroscientists, psychiatrists, neurologists, and neuropsychologists and reflect how the parallel loop model is currently used to conceptualize limbic, cognitive, and motor aspects of brain disease. The book contains many diagrams and schematics throughout, and there are eight color plates to illustrate anatomic concepts and imaging data.
The book is divided into three parts. The first part provides a review of anatomy, neurochemistry, and physiology of corticobasal ganglia circuits. Middleton and Strick propose a revised version of the fronto-subcortical circuits model in chapter 2. Changes …
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