This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
We describe the occurrence of the anti-myelin-associated glycoprotein (anti-MAG) syndrome, a well-recognized variant of chronic inflammatory demyelinating polyneuropathy (CIDP) with distinct clinical and electrophysiologic characteristics, in two brothers.
Case 1.
A 70-year-old man presented with symmetric numbness distal to his knees, followed by progressive imbalance and gait unsteadiness that developed over 2 years. His similarly affected brother is described below (Case 2); there was no other relevant family history. On examination he had mild distal weakness in both lower limbs and symmetric vibration and proprioceptive loss distally in all four limbs. Muscle stretch reflexes were absent. Gait was severely ataxic and Romberg's sign was present. Nerve conduction studies revealed a severe demyelinating polyneuropathy with disproportionate distal slowing, prolongation of F waves without evidence of conduction block, and met criteria for CIDP.1 Immunoglobulin M (IgM) kappa monoclonal gammopathy was identified; IgM was 235 mg/dL (normal, 50 to 200 mg/dL) of which 50% to 90% was monoclonal and anti-MAG reactivity was positive at a titer of …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Topics Discussed
Alert Me
Recommended articles
Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy
The Wide Spectrum of Pathophysiologic Mechanisms of Paraproteinemic Neuropathy
Intermittent cyclophosphamide and prednisone treatment of polyneuropathy associated with monoclonal gammopathy of undetermined significance
Malignant transformation in polyneuropathy associated with monoclonal gammopathy