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July 26, 2005; 65 (2) Brief Communications

The smoking–thrombolysis paradox and acute ischemic stroke

Bruce Ovbiagele, Jeffrey L. Saver
First published June 15, 2005, DOI: https://doi.org/10.1212/01.WNL.0000168163.72351.f3
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Abstract

Smokers with acute myocardial infarction have better outcomes after thrombolysis than nonsmokers. The authors evaluated the independent effect of smoking on short-term outcome following IV thrombolysis for acute ischemic stroke. After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year.

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Letters: Rapid online correspondence

  • Reply to Fisher
    • Bruce Ovbiagele, Stroke Center and Department of Neurology, 710 Westwood Blvd., Rm 1-240, Los Angeles, CA 90095
    • Jeffrey L. Saver
    Submitted August 31, 2005
  • The smoking/thrombolysis paradox and acute ischemic stroke
    • Mark Fisher, Department of Neurology, UC Irvine, UCI Medical Center, 101 The City Dr. South, Bldg 55, Rm 121, Orange, CA 92868
    Submitted August 31, 2005
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