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Abstract
The authors assessed the effect of IV abciximab on early neurologic improvement and ischemic lesion growth in 29 patients with supratentorial stroke and NIH stroke scale score (NIHSSS) ≥ 4 (11.1 ± 5.9), treated within 3 to 24 (13.6 ± 5.5) hours of onset. The 48 to 72-hour NIHSSS improvement was 4.4 ± 3.2 and the 24-hour lesion growth on DWI was +23% (−50%, +103%); 7/26 (27%) patients experienced lesion size decrease. Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth.
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- MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window
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