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May 22, 2007; 68 (21) Clinical/Scientific Notes

LAMBERT-EATON MYASTHENIC SYNDROME WITH PURE OCULAR WEAKNESS

Stacy A. Rudnicki
First published May 21, 2007, DOI: https://doi.org/10.1212/01.wnl.0000264798.56174.df
Stacy A. Rudnicki
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LAMBERT-EATON MYASTHENIC SYNDROME WITH PURE OCULAR WEAKNESS
Stacy A. Rudnicki
Neurology May 2007, 68 (21) 1863-1864; DOI: 10.1212/01.wnl.0000264798.56174.df

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Complaints of double vision or droopy eyelids have been reported in 0 to 65% of patients with Lambert–Eaton myasthenic syndrome (LEMS), although in none of these series was it the only complaint.1–3 Two cases of patients with solely ocular complaints initially but an overlap of LEMS and myasthenia gravis (MG) have been previously reported.4,5 This is a report of an LEMS patient with weakness limited to ocular muscles.

Case report.

A 52-year-old woman presented with an 8-month history of diplopia starting abruptly and initially constant. Subsequently, it became intermittent and evoked by lateral gaze. She noticed occasional droopiness of her eyelids. Her only other recent complaints were fatigue and a 19-pound weight gain over 1 year, which she attributed to lacking the energy to exercise. Dry mouth had been present for several years. She was disabled by rheumatoid arthritis, which had affected multiple other family members. She smoked one and a half packs of cigarettes per day for …

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Letters: Rapid online correspondence

  • LAMBERT-EATON MYASTHENIC SYNDROME WITH PURE OCULAR WEAKNESS
    • Maarten J. Titulaer, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC Leiden, the Netherlandsm.j.titulaer@lumc.nl
    • Paul W. Wirtz , Axel R. Wintzen , Jan J.G.M. Verschuuren
    Submitted July 31, 2007
  • Reply from the author
    • Stacy A Rudnicki, University of Arkansas for Medical Science, 4301 W. Markham, Little Rock, AR 72205sarudnicki@uams.edu
    Submitted July 31, 2007
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Topics Discussed

  • Myasthenia
  • Lambert-Eaton syndrome
  • Diplopia (double vision)
  • Paraneoplastic syndrome

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