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In this issue of Neurology, Edison et al.1 present a study which compares a newly developed amyloid imaging technique (PIB PET) pioneered by Klunk et al.2 and glucose metabolism (FDG PET) imaging to cognitive testing in Alzheimer disease (AD). They expand the observation that PIB PET is highly sensitive (89%) and specific for clinical AD compared to normal age-matched controls. They demonstrate correlation of recognition memory tests with PIB PET, as well as other memory testing with temporal and hippocampal FDG PET. In addition, they demonstrate that PIB PET imaging correlates with decreased glucose utilization in the temporal and parietal cortex, but not in the frontal cortex. PIB PET is a molecular amyloid imaging technique, and has potential for providing quantitative measures of amyloid in the brain,3 which previously could only be obtained postmortem. The utility of PIB PET will depend on the questions being asked of the test.
PIB PET may be evaluated for diagnostic purposes, such …
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