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To the Editor:
Ciampi de Andrade et al.1 report that two-thirds of patients with neurocysticercosis (NCYST) show cognitive impairment and attributed this to a synergistic interaction of cysticercus lesions and local inflammation.1 We believe that other possible mechanisms for cognitive dysfunction in NCYST should be considered.
NCYST affects brain regions that are distant from the location of the cysticerci.2 For example, cysticercosis might cause hippocampal dysfunction prompting epilepsy or cognitive impairment even when lesions are located outside the limbic system.2 Although inflammation may be a cause, other more sophisticated biologic mechanisms related to host–parasite interactions need to be addressed.
Parasites may induce expression of several classes of genes in the CNS of the host and exceeds the gene …
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