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Abstract
Background: Quantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic generalized epilepsy (IGE). However, there are few studies examining IGE early in its course and the neurodevelopmental course of this region is not adequately defined.
Objective: We examined the 2-year developmental course of the thalamus and frontal lobes in pediatric new-onset IGE (i.e., within 12 months of diagnosis).
Methods: We performed whole-brain MRI in 22 patients with new-onset IGE and 36 age-matched healthy controls. MRI was repeated 24 months after baseline MRI. Quantitative volumetrics were used to examine thalamic and frontal lobe volumes.
Results: The IGE group showed significant differences in thalamic volume within 1 year of seizure onset (baseline) and went on to show thalamic volume loss at a significantly faster rate than healthy control children over the 2-year interval. The control group also showed a significantly greater increase in frontal white matter expansion than the IGE group. In contrast, frontal lobe gray matter volume differences were moderate at baseline and persisted over time, indicating similar developmental trajectories with differences early in the disease process that are maintained.
Conclusions: Brain tissue abnormalities in thalamic and frontal regions can be identified very early in the course of IGE and an abnormal trajectory of growth continues over a 2-year interval.
Footnotes
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Study funding: Supported by NIH NINDS RO1 44351 and 1UL1RR025011 from the Clinical and Translational Science Award (CTSA) program of the National Center for Research Resources and from the Epilepsy Foundation.
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- AED
- antiepileptic drugs
- ANCOVA
- analysis of covariance
- FOV
- field of view
- ICV
- intracranial volume
- IGE
- idiopathic generalized epilepsy
- NEX
- number of excitations
- TE
- echo time
- TR
- repetition time
- Received December 20, 2009.
- Accepted May 20, 2010.
- Copyright © 2010 by AAN Enterprises, Inc.
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