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Abstract
Objectives: In multiple sclerosis (MS), contrast-enhancing lesions (CELs) in T1-weighted postcontrast MRI are considered markers of blood–brain barrier breakdown. It remains unknown if re-enhancement can be considered a radiologic indicator of different pathology in CELs. We investigated 1) the incidence of re-enhancing lesions (re-CELs) from chronic lesions; 2) differences in size, magnetization transfer ratio (MTR), and likelihood to appear as acute black holes (aBHs) between new lesions (n-CELs) and re-CELs; and 3) associations between re-CELs and features indicating more advanced disease.
Methods: In this retrospective natural history study, we examined 264 monthly MRI scans performed at month 1 (M1), month 2 (M2), and month 3 (M3) for 88 patients with MS. CELs were defined as n-CELs if not present in the M1 T2W MRI and re-CELs if present in the M1 T2W MRI.
Results: A total of 311 (82.7%) n-CELs and 65 (17.3%) re-CELs were identified. Of the 88 patients, 54 presented only n-CELs, 8 presented only re-CELs, and 26 presented both CEL types. Patients with both lesion types presented more CELs than those presenting only one type (p = 0.01). Re-CELs were larger (z = 2.72, p = 0.007) and had lower MTR (z = −2.80, p = 0.005) than n-CELs but the estimated proportion of aBHs from n-CELs was similar (z = −0.09, p = 0.1) from the proportion of aBHs from re-CELs.
Conclusions: Nearly 20% of CELs represent the reoccurrence of enhancement in chronic plaques. Re-CELs represent larger areas of inflammation, not necessarily associated with larger areas of edema.
GLOSSARY
- aBH=
- acute black hole;
- BBB=
- blood–brain barrier;
- CEL=
- contrast-enhancing lesion;
- EDSS=
- Expanded Disability Status Scale;
- FLAIR=
- fluid-attenuated inversion recovery;
- Gd=
- gadolinium;
- GEE=
- generalized estimating equation;
- MS=
- multiple sclerosis;
- MTR=
- magnetization transfer ratio;
- n-CEL=
- new contrast-enhancing lesion;
- NIB=
- Neuroimmunology Branch;
- NINDS=
- National Institute of Neurological Diseases and Stroke;
- re-CEL=
- re-enhancing lesion;
- SE=
- spin echo
Footnotes
Study funding: Supported by the Intramural Research Program of the NINDS-NIH.
Supplemental data at www.neurology.org
- Received May 10, 2011.
- Accepted December 29, 2011.
- Copyright © 2012 by AAN Enterprises, Inc.
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