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September 25, 2012; 79 (13) Editorials

Subjective cognitive impairment

Fickle but fateful

David S. Knopman
First published August 22, 2012, DOI: https://doi.org/10.1212/WNL.0b013e31826c1bd1
David S. Knopman
From the Alzheimer's Disease Research Center, Department of Neurology, Mayo Clinic, Rochester, MN.
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Subjective cognitive impairment
Fickle but fateful
David S. Knopman
Neurology Sep 2012, 79 (13) 1308-1309; DOI: 10.1212/WNL.0b013e31826c1bd1

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This article has a correction. Please see:

  • Subjective cognitive impairment: Fickle but fateful - January 22, 2013
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Memory is a fragile, fickle thing. Almost every adult experiences a memory lapse occasionally. In younger people, shrugging it off or ignoring it may be the norm. As people hit their 40s, resignation that memory loss is a consequence of aging creeps into the apologies. In the 21st century, the possibility that memory lapses represent Alzheimer disease (AD) dementia has fostered a new anxiety. The specter of “Alzheimer's” lurking in everyday memory lapses tends to make a name forgotten or a set of keys misplaced all the more memorable.

Almost like the famous Catch-22, conventional wisdom about memory complaints, without objective evidence of impairment, had been that if someone had enough insight to …

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