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Abstract
Objective: To quantitatively synthesize results from neuroimaging studies that evaluated patterns of resting functional activity in patients with disorders of consciousness (DOC).
Methods: We performed a systematic review and coordinate-based meta-analysis of studies published up to May 2014. Studies were included if they compared resting-state functional neuroimaging data acquired in patients with DOC (coma, minimally conscious state, emergence from minimally conscious state, or vegetative state) with a group of healthy controls. Coordinate-based meta-analysis was performed in studies that included voxel-based comparisons at the whole-brain level and if analysis was accomplished with data-driven approaches.
Results: A total of 36 studies (687 patients, 637 healthy controls) were included in the systematic review. Reported DOC were vegetative state (43.2%), coma (23.4%), minimally conscious state (22.8%), and emergence from minimally conscious state (1.6%); the most common etiologies of DOC were traumatic brain injury (37.7%) and anoxic brain injury (36.9%). Functional neuroimaging was accomplished using fMRI (16 studies), PET (15 studies), SPECT (4 studies), and both PET and SPECT in one study. Meta-analysis in 13 studies (272 patients, 259 healthy controls) revealed consistently reduced activity in patients with DOC in bilateral medial dorsal nucleus of the thalamus, left cingulate, posterior cingulate, precuneus, and middle frontal and medial temporal gyri.
Conclusions: In patients with DOC evaluated in the resting state, functional neuroimaging indicates markedly reduced activity within midline cortical and subcortical sites, anatomical structures that have been linked to the default-mode network. Studies are needed to determine the relation between activation (and coherence) within these structures and the emergence of conscious awareness.
GLOSSARY
- ALE=
- activation likelihood estimate;
- ALFF=
- amplitude of low-frequency fluctuations;
- BOLD=
- blood oxygen level–dependent;
- CRS-R=
- Coma Recovery Scale–Revised;
- DMN=
- default mode network;
- DOC=
- disorders of consciousness;
- EMCS=
- emergence from minimally conscious state;
- FDG=
- fluorodeoxyglucose;
- HC=
- healthy control;
- ICA=
- independent component analysis;
- MCS=
- minimally conscious state;
- MNI=
- Montreal Neurological Institute;
- PCC=
- posterior cingulate cortex;
- ReHo=
- regional homogeneity;
- ROI=
- region of interest;
- TBI=
- traumatic brain injury;
- VS=
- vegetative state
Footnotes
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Supplemental data at Neurology.org
- Received September 23, 2014.
- Accepted in final form December 4, 2014.
- © 2015 American Academy of Neurology
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Letters: Rapid online correspondence
- Author reply: DoC: a pathophysiological continuum with high variabiity?
- Author reply:Too less experiments for an ALE-meta analysis?
- DoC: a pathophysiological continuum with high variabiity?
- Too less experiments for an ALE-meta analysis?
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