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February 05, 2019; 92 (6) Article

Recurrent stroke in midlife is associated with not having a primary care physician

Rebecca J. Lank, Lynda D. Lisabeth, Brisa N. Sánchez, Darin B. Zahuranec, Kevin A. Kerber, Lesli E. Skolarus, James F. Burke, Deborah A. Levine, Erin Case, Devin L. Brown, Lewis B. Morgenstern
First published January 4, 2019, DOI: https://doi.org/10.1212/WNL.0000000000006878
Rebecca J. Lank
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Lynda D. Lisabeth
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Brisa N. Sánchez
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Darin B. Zahuranec
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Kevin A. Kerber
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Lesli E. Skolarus
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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James F. Burke
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Deborah A. Levine
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Erin Case
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Devin L. Brown
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Lewis B. Morgenstern
From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
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Citation
Recurrent stroke in midlife is associated with not having a primary care physician
Rebecca J. Lank, Lynda D. Lisabeth, Brisa N. Sánchez, Darin B. Zahuranec, Kevin A. Kerber, Lesli E. Skolarus, James F. Burke, Deborah A. Levine, Erin Case, Devin L. Brown, Lewis B. Morgenstern
Neurology Feb 2019, 92 (6) e560-e566; DOI: 10.1212/WNL.0000000000006878

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Abstract

Objective To determine using a population-based study whether midlife stroke patients having a primary care physician (PCP) at the time of first stroke have a lower risk of stroke recurrence and mortality than those who do not have a PCP.

Methods First-ever ischemic stroke patients 45 to 64 years of age at stroke onset were ascertained through the Brain Attack Surveillance in Corpus Christi (BASIC) project from 2000 to 2013 in Texas. Cox proportional hazards models were used to examine the association between not having a PCP and stroke recurrence or all-cause mortality in separate models. Cases were followed up for up to 5 years or until December 31, 2013, whichever came first. Cases were censored for recurrence if they died before experiencing a recurrent event. We adjusted for clinical risk factors that could be associated with having a PCP and recurrence or mortality.

Results There were 663 first-occurrence ischemic stroke cases. Of these, 77% had a PCP, 43% were female, and average age was 55.6 years. Five-year recurrence risk was 14.6%, and mortality risk was 19.2%. Not having a PCP was associated with higher recurrence risk (adjusted hazard ratio 1.75, 95% confidence interval 1.02–3.02). Having a PCP was not associated with mortality. Sensitivity analyses showed that results were robust to different ways to adjust for chronic conditions.

Conclusion This study found lower rates of stroke recurrence among those with a PCP at the time of first stroke. Future studies could determine the value of establishing a PCP before stroke hospital discharge for secondary stroke prevention.

Glossary

BASIC=
Brain Attack Surveillance in Corpus Christi;
CI=
confidence interval;
HR=
hazard ratio;
ICD=
International Classification of Diseases;
IRB=
Institutional Review Board;
NIHSS=
NIH Stroke Scale;
PCP=
primary care physician

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • CME Course: NPub.org/cmelist

  • Received May 24, 2018.
  • Accepted in final form October 8, 2018.
  • © 2019 American Academy of Neurology
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