文摘
摘要目的:描述偏手性的发育特征和语言学习障碍在原发性进行性失语。
背景:原发性进行性失语由3变种- logopenic、迟滞型和语义。每个子类型与不同的解剖参与和通常用离散潜在的病理。之前文学发展的PPA表明与神经发育相关证明学习障碍的增加率在PPA患者和2例左hemicranial发育不全在PPA语义变体。
设计/方法:我们筛选UCSF记忆和衰老中心的PPA队列手偏好和LD的历史。这项研究包括logopenic变体PPA (lvPPA), n = 47;迟滞型变体PPA (nfvPPA), n = 54;语义变体(svPPA), n = 96。svPPA的独立样本,n = 36岁的梅奥诊所提供的杰克逊维尔和PSP, n = 107,来自加州大学旧金山分校是专为偏手性筛查。
结果:有近两倍的患病率nRH svPPA队列,在nfvPPA nRH患病率的一半,nRH符合lvPPA偏手性一般人群。这些构型的研究结果证实了我们的独立组织。lvPPA组有更大的可能性LD相比svPPA和nfvPPA组。在lvPPA集团LD患者年轻和增加了全球功能演示比lvPPA没有LD。
结论:手偏好的一种独特形式和历史的语言学习障碍似乎与每个亚型PPA强烈相关。这进一步加强了PPA的前期研究结果,可以提供新的见解神经发育如何影响神经退行性疾病易感性。
支持:美国国立卫生研究院(赠款P01 AG19724, P50 AG023501, P50 AG1657303, P50AG16574, R01-AG032306,和R01 NS050915-05A1)和它的内容是完全的责任作者,不一定代表国家老化研究所的官方观点或国家卫生研究院。额外资金包括额颞叶痴呆研究财团,NSF研究生研究奖学金,τ研究财团。
披露:米勒博士没有披露。Rankin博士没有披露。没有披露的铜质把手博士。博士亨利没有披露。威尔逊博士没有披露。Babiak博士没有披露。弗雷泽博士没有披露。Bettcher博士没有披露。吴博士没有披露。博士没有披露。 Dr. Ketelle has nothing to disclose. Dr. Edwards has nothing to disclose. Dr. Heggeli has nothing to disclose. Dr. Rosen has nothing to disclose. Dr. Kramer has nothing to disclose. Dr. Rabinovici has received personal compensation for activities with Eli Lilly & Company......Dr. Rabinovici has received research support from Avid Radiopharmaceuticals and Eli Lilly & Company. Dr. Graff-Radford has received personal compensation for activities with Codman. Dr. Graff-Radford has received personal compensation in an editorial capacity for the Neurologist. Dr. Graff-Radford has received research support from Janssen, Pfizer Pharmaceuticals, Medivation, Forrest, and Allon. Dr. Seeley has received personal compensation for activities with Korea Novartis, Summer Street Research Partners and Bristol-Myers Squibb for speaker, consulting and scientific advisory boards. Dr. Miller has received personal compensation for activities with Allon Therapeuctics, Inc. and TauRx Therapeutics, Ltd. Dr. Miller has received research support from Novartis. Dr. Gorno Tempini has nothing to disclose.
2013年3月19日,星期二,下午2:00 pm-6:30
- 版权©2013年长企业公司,。
