文摘
目的:研究结果在静脉注射组织纤溶酶原激活物(IV-tPA)与急性缺血性中风间。背景:数据显示八旬老人少有利post-IV-tPA-administration结果比年轻病人。方法:横断面研究分析2013 - 2015年从托马斯杰弗逊大学医院远程医疗中风病人数据网络。主要结果是贫穷的结果(长期护理或死亡)出院。二次结果是出血性转换。我们比较的结果八旬老人(病人80 - 89岁)与年轻患者。我们使用美国国立卫生研究院的中风尺度(署)录取(α)和放电(δ)署分数作为神经恶化和计算中位数不同的代理人(Δ-NIHSS)对使用Wilcoxon-Signed-Rank匹配测试。更高的署分数代表了更严重的症状。我们使用逻辑回归来确定预测的结果。结果:这项研究涉及197名患者(平均年龄69±16年),包括52个八旬老人和104名妇女。 Median αNIHSS was 9 (Interquartile Range [IQR] 14) and median δNIHSS 6 (IQR 15). The IV-tPA-administration rate was similar among groups at 50[percnt]. The octogenarian group had a higher median αNIHSS (16, IQR 16 vs. 8, IQR 11, p≤0.01), more women (69[percnt] vs. 45[percnt], p.003), and a higher poor-outcome rate (61[percnt] vs. 23[percnt], p≤0.0001) than the younger group, but no in-hospital mortality (25[percnt] vs. 14[percnt], p=0.09). Younger patients had a higher median Δ-NIHSS than octogenarians (5 vs. 0, p.0.001). Adjusting for age, sex, IV-tPA, year, and physician, poor outcome predictors were octogenarian (OR 4.1; CI, 1.6-10.9, p.0.003) and αNIHSS>9 (OR 8.7; CI, 3.7-22.7, p<0.0001). We observed an interaction with poor outcome and IV-tPA for octogenarians (OR 1.9; CI, 1.2-3.1, p=0.007) only. All groups had similar cumulative hemorrhagic-conversion rates (3[percnt]). Conclusions: Older patients had a higher risk of poor outcome at hospital discharge and this effect was independent of hemorrhagic transformation or in-hospital neurological deterioration.
披露:坎波斯博士没有披露。桑切斯博士没有披露。Deprince博士没有披露。Vibbert博士没有披露。《博士没有披露。阿特博士没有披露。博士酒吧没有披露。曾博士没有披露。希恩博士没有披露。皮内博士没有披露。 Dr. Bell has nothing to disclose. Dr. Tjoumakaris has nothing to disclose. Dr. Jabbour has nothing to disclose. Dr. Rosenwasser has nothing to disclose. Dr. Rincon has nothing to disclose.
星期六,2016年4月16日,8:30 am-7:00点
- 版权©2016年长企业公司,。
