文摘
摘要目的:识别peri-ictal呼吸干扰与postictal广义脑电图抑制(网页)和睡眠。
背景:Seizure-related呼吸功能障碍可能会使癫痫突然意外死亡(癫痫),然而,现有的研究主要基于头皮录音和缺乏全面的障碍(PSG)信号。网页(缺乏脑电图活动> 10μv)提出了生物标志物的癫痫和癫痫发生在大多数情况下睡觉。
设计/方法:我们研究呼吸变化stereoelectroencephalography (SEEG)记录perisylvian发作使用多通道系统集成脑电图和PSG信号包括气流,努力,热点2、有限公司2。睡眠状态和网页是由头皮电极(FZ / CZ)。可翻译的录音需要热点;2和至少一个通道气流和工作。呼吸事件得分在焦和推广阶段。事件的频率和持续时间是由州和网页状态相比使用两个示例t检验或克鲁斯卡尔-沃利斯检验基于0.05显著性水平使用SAS 9.4软件。
结果:61年癫痫(29例)包括在内。相比癫痫没有网页,网页癫痫(N = 8)与中央的事件的发生频率更高(中值(差):3.0(3.0,4.0)和1.0 (1.0,1.0),P < 0.001)和持续时间(76(63、94)和27 12.5,35秒,P = 0.010);更高的猝发的RR(平均数±标准差:bpm 28.5±1.5 vs 24.6±4.6, P < 0.001), pre-ictal-to-ictal RR变化(bpm 8.1±3.2 vs 2.3±3.2, P < 0.001)和pre-ictal-to-peak TcpCO2改变(16.4 [11.6,31.0]vs 2.2[0.45, 7.2]毫米汞柱,P = 0.023);和更大的pre-ictal-to-nadir热点;2改变(24.0 [23.0,24.4]vs 4.1 [2.4, 11.0] %, P = 0.033)。然而,网页与睡眠状态无关。相比之下,睡眠发作(N = 35)从后癫痫只有低分化pre-ictal (bpm 19.9±2.5 vs 24.1±3.1, P < 0.001),发作的(22.6±4.3 vs 28.0±2.7 bpm, P < 0.001), postictal RR (bpm 24.7±5.22 vs 8.5±4.4, P = 0.020),和更高的pre-ictal TcpCO236.8(40.6[38.1,42.6]和[32.8,39.5]毫米汞柱,P = 0.006)。
结论:网页(而不是睡眠)perisylvian癫痫与主机相关的呼吸障碍,提供进一步支持作为生物标志物的癫痫。
披露:莫拉穆尼奥斯博士没有披露。诺亚安德鲁斯没有披露。Araujo博士已经收到个人赔偿作为国际商业机器的员工。Araujo博士已经收到个人薪酬在500 - 4999美元的范围为默克公司担任顾问。Araujo已收到博士研究激励医疗系统的支持。Araujo博士已经收到个人薪酬在500 - 4999美元的范围作为一个心脏健康顾问。Aboussouan博士已经收到相关出版物的出版版税卫生保健。威廉·宾格曼没有披露。鲁王没有披露。Grigg-Damberger博士已经收到个人赔偿担任牛津大学出版社的一个员工。 Dr. Grigg-Damberger has received personal compensation for serving as an employee of Up-to-date. Dr. Grigg-Damberger has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Sleep Medicine. Dr. Grigg-Damberger has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Jazz. The institution of Dr. Foldvary-Schaefer has received research support from Suven. The institution of Dr. Foldvary-Schaefer has received research support from Takeda. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care. Dr. Foldvary-Schaefer has received publishing royalties from a publication relating to health care.
